This is a pretty cool video demonstration Rhonda Forever, a 3D Drawing software developed by Amir Pitaru in 2003.
Pitaru is a classically trained musician but makes really badass digital art with his own custom programs. The coolest part is, he has no formal computer programming training; he's completely self-taught. The Design Museum website says he strives to create interactive animations with the same fluency as music, which is pretty obvious once you take a look at his stuff. This one is call "Geisha", also made with another custom software. You can check out more of his work at pitaru.com.
The hands & drawings in the video belong to James Paterson (no, not the guy that writes those paperback novels my mom reads), another self-taught software geek. So the interwebz say, the two of them met at a conference in London, then realizing they lived on the same street in Brooklyn, and started collaborating. His stuff is a little more my taste than Pitaru's; kindof purposely rough figural line drawings. He likes to use the computer "like a sketchbook". He's has a few creative outlets on the web but I like halfempty.com/james most.
BONUS: If you visit the site, there is a field at the bottom of the page to sign up to be a tester. They'll e-mail you a password to download the prototype to play around with. I already got mine!